Studies on the Electron Transfer System

Studies on the Electron Transfer System

The study of the terminal electron transfer system has been approached essentially in two ways. The first approach has been by way of the study of electron transfer in intact cells and in respiratory chain particles such as mitochrondria; it can best be exemplified by the studies of Chance and Williams (1). The second approach, which has been used in this laboratory, involves fragmentation of m...

Studies on the electron transfer system. XLV. Some effects of antimycin on cytochrome b.

It has been known for some time that antimycin A modifies the enzymic properties of cytochrome b. Chance (1) reported that cytochrome b was reduced at a much faster rate in heart muscle preparation blocked by antimycin A than in a preparation blocked by cyanide; moreover, cytochrome b was reduced to a greater extent in the presence than in the absence of antimycin A. From a study of difference ...

Studies on the Terminal Electron Transport System

The present communication is devoted to the description of the isolation, properties, and composition of a particulate unit which we shall refer to as the succinic dehydrogenase complex (SDC). The working hypothesis underlying this and subsequent communications in this series is that SDC is a unit of enzymatic action in the same sense as any well defined soluble enzyme. Since the discovery of s...

Studies on the Electron Transfer System. Lxii. the Reaction of Cytochrome Oxidase with Carbon Monoxide.

The participation of molecular oxygen in biological oxidations is catalyzed by an enzyme which has been called-a variety of names starting with Atmungsfemzent by Warburg (18) to the currently employed term of cytochrome oxidase proposed by Keilin and Hartree (11). Presumably the enzyme functions by first combining with molecular oxygen and then becoming oxidized by it. As first shown by Warburg...

Studies on the electron transfer system. XL. Preparation and properties of mitochondrial DPNH-coenzyme Q reductase.